Further Information
Serine/threonine-protein kinase WNK1, 2.7.11.1, Erythrocyte 65 kDa protein, p65, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, hWNK1, WNK1, HSN2, KDP, KIAA0344, PRKWNK1
For WB starting dilution is: 1:2000
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
- Verissimo F.,et al.Oncogene 20:5562-5569(2001).
- Vidal-Petiot E.,et al.PLoS ONE 7:E37751-E37751(2012).
- Scherer S.E.,et al.Nature 440:346-351(2006).
- Moore T.M.,et al.J. Biol. Chem. 275:4311-4322(2000).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This WNK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1848-1882 amino acids from human WNK1.
65125
Serine/threonine-protein kinase WNK1
WNK1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
251 kDa
Q9H4A3
296453029
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
Q9H4A3
Optimal dilutions for each application to be determined by the researcher.