ProSci

Guanylyl Cyclase alpha 2 Antibody

Product Code:
 
PSI-63-447
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti-GUCY1A2 Antibody in NCI-H460 cell line lysates (35ug/lane)
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.
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Western blot analysis of anti-GUCY1A2 Antibody in NCI-H460 cell line lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.

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PSI-63-447-400ul400ul£626.00
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Further Information

Additional Names:
Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2, GUCY1A2, GUC1A2, GUCSA2
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
Background:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Background References:
  • Baba, H., et al., Neuroreport 15(4):677-680 (2004).
  • Bellamy, T.C., et al., Proc. Natl. Acad. Sci. U.S.A. 99(1):507-510 (2002).
  • Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).
  • Bamberger, A.M., et al., J. Clin. Endocrinol. Metab. 86(2):909-912 (2001).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Guanylyl Cyclase alpha 2 (GUCY1A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-732 amino acids from the C-terminal region of human Guanylyl Cyclase alpha 2 (GUCY1A2).
NCBI Gene ID #:
2977
NCBI Official Name:
Guanylate cyclase soluble subunit alpha-2
NCBI Official Symbol:
GUCY1A2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
82 kDa
Protein Accession #:
P33402
Protein GI Number:
461897
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
P33402
User NOte:
Optimal dilutions for each application to be determined by the researcher.