ProSci

C-rel Antibody

Product Code:
 
PSI-62-252
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of lysate from Daudi cell line, using C-rel (NFkB)-G601 Antibody at 1:1000 at each lane.
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Western blot analysis of anti-C-rel (NFkB) Pab (AP6336c)in Jurkat (left) and mouse kidney (right) cell line lysate.
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Western blot analysis of lysate from Daudi cell line, using C-rel (NFkB)-G601 Antibody at 1:1000 at each lane.
Western blot analysis of anti-C-rel (NFkB) Pab (AP6336c)in Jurkat (left) and mouse kidney (right) cell line lysate.

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PSI-62-252-400ul400ul£626.00
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Further Information

Additional Names:
Proto-oncogene c-Rel, REL
Application Note:
For WB starting dilution is: 1:1000
Background:
Nuclear factor (NF)-kappa B is a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB regulates the expression of a wide variety of genes that involved in apoptosis, viral life cycle, tumorigenesis, autoimmune diseases and inflammation. NF-kB is a heterodimer of members of the rel family of proteins such as p50, p65, and c-rel. In most cells, inhibitory IkB proteins sequester NF-kB/Rel in the cytoplasm. Cellular stimulation precipitates degradation of IkB and modification of NF-kB/Rel proteins, permitting translocation of NF-kB/Rel (c-Rel and RelA) to the nucleus for action on target genes. The important role of c-Rel in B-cell development, growth, and survival has been intensively studied, as well as its function in differentiation and lymphopoiesis (particularly lymphoid cancer).
Background References:
  • Jain, A., et al., J. Clin. Invest. 114(11):1593-1602 (2004).
  • Xiao, Q., et al., Appl. Immunohistochem. Mol. Morphol. 12(3):211-215 (2004).
  • Houldsworth, J., et al., Blood 103(5):1862-1868 (2004).
  • Phelps, C.B., et al., Oncogene 23(6):1229-1238 (2004).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This C-rel (NFkB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-619 amino acids from the C-terminal region of human C-rel (NFkB).
NCBI Gene ID #:
5966
NCBI Official Name:
Proto-oncogene c-Rel
NCBI Official Symbol:
REL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
69 kDa
Protein Accession #:
Q04864
Protein GI Number:
548720
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q04864
User NOte:
Optimal dilutions for each application to be determined by the researcher.