ProSci

ASCL1 Antibody

Product Code:
 
PSI-60-921
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect Hash1 in mouse lung tissue lysate.
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Antibody is used in Western blot to detect Hash1 in mouse lung tissue lysate.

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PSI-60-921-400ul400ul£626.00
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Further Information

Additional Names:
Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Application Note:
For WB starting dilution is: 1:1000
Background:
ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.
Background References:
  • Sriuranpong, V., et al., Mol. Cell. Biol. 22(9):3129-3139 (2002). Westerman, B.A., et al., Clin. Cancer Res. 8(4):1082-1086 (2002). Chen, H., et al., Cell Growth Differ. 8(6):677-686 (1997). Borges, M., et al., Nature 386(6627):852-855 (1997). Renault, B., et al., Genomics 30(1):81-83 (1995).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This ASCL1 (Achaete-scute homolog 1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human ASCL1 (Achaete-scute homolog 1).
NCBI Gene ID #:
429
NCBI Official Name:
Achaete-scute homolog 1
NCBI Official Symbol:
ASCL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Protein Accession #:
P50553
Protein GI Number:
20455478
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Neuroscience
Swissprot #:
P50553
User NOte:
Optimal dilutions for each application to be determined by the researcher.