ProSci

FIG4 Antibody

Product Code:
 
PSI-59-674
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis in Jurkat cell line lysates (35ug/lane).
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Western blot analysis in mouse kidney tissue lysates (35ug/lane).
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
Western blot analysis in mouse kidney tissue lysates (35ug/lane).

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PSI-59-674-400ul400ul£626.00
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Further Information

Additional Names:
Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
Background References:
  • Ikonomov, O.C., et al. J. Biol. Chem. 285(35):26760-26764(2010)
  • Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
  • Ikonomov, O.C., et al. J. Biol. Chem. 284(51):35794-35806(2009)
  • Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.
NCBI Gene ID #:
9896
NCBI Official Name:
Polyphosphoinositide phosphatase
NCBI Official Symbol:
FIG4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Protein Accession #:
Q92562
Protein GI Number:
2497367
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q92562
User NOte:
Optimal dilutions for each application to be determined by the researcher.