ProSci

SPR Antibody

Product Code:
 
PSI-64-203
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 ug per lane.
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Western blot analysis of SPR Antibody in mouse liver tissue lysates (35ug/lane)
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Western Blot at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of SPR Antibody in mouse liver tissue lysates (35ug/lane)

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PSI-64-203-400ul400ul£626.00
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Further Information

Additional Names:
Sepiapterin reductase, SPR, SPR
Application Note:
For WB starting dilution is: 1:1000
Background:
SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
Background References:
  • Leu-Semenescu, S., et al. Sleep 33(3):307-314(2010) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009) Clot, F., et al. Brain 132 (PT 7), 1753-1763 (2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human SPR.
NCBI Gene ID #:
6697
NCBI Official Name:
Sepiapterin reductase
NCBI Official Symbol:
SPR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
P35270
Protein GI Number:
464801
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
P35270
User NOte:
Optimal dilutions for each application to be determined by the researcher.