ProSci

PPP4R2 Antibody

Product Code:
 
PSI-59-916
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse brain tissue lysates (35ug/lane).
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Western blot analysis in mouse brain tissue lysates (35ug/lane).

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PSI-59-916-400ul400ul£626.00
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Further Information

Additional Names:
Serine/threonine-protein phosphatase 4 regulatory subunit 2, PPP4R2
Application Note:
For WB starting dilution is: 1:1000
Background:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Background References:
  • Lee, D.H., et al. Nat. Struct. Mol. Biol. 17(3):365-372(2010)
  • Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)
  • Chowdhury, D., et al. Mol. Cell 31(1):33-46(2008)
  • Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PPP4R2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-254 amino acids from the Central region of human PPP4R2.
NCBI Gene ID #:
151987
NCBI Official Name:
Serine/threonine-protein phosphatase 4 regulatory subunit 2
NCBI Official Symbol:
PPP4R2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q9NY27
Protein GI Number:
158564082
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9NY27
User NOte:
Optimal dilutions for each application to be determined by the researcher.