Further Information
Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CYTH3, ARNO3, GRP1, PSCD3
For WB starting dilution is: 1:1000
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
- Morishige, M., et al. Nat. Cell Biol. 10(1):85-92(2008)
- Poirier, M.B., et al. Mol. Endocrinol. 19(8):1991-2005(2005)
- Nevrivy, D.J., et al. J. Biol. Chem. 275(22):16827-16836(2000)
- Ogasawara, M., et al. J. Biol. Chem. 275(5):3221-3230(2000)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat
This CYTH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human CYTH3.
9265
Cytohesin-3
CYTH3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
O43739
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
O43739
Optimal dilutions for each application to be determined by the researcher.