ProSci

OAS1 Antibody

Product Code:
 
PSI-62-189
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Antibody is used in Western blot to detect OAS1 in mouse liver lysate.
2 / 2
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Antibody is used in Western blot to detect OAS1 in mouse liver lysate.
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-62-189-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
2'-5'-oligoadenylate synthase 1, (2-5')oligo(A) synthase 1, 2-5A synthase 1, E18/E16, p46/p42 OAS, OAS1, OIAS
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Background References:
  • Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
  • Sarkar, S.N., et al., J. Biol. Chem. 274(36):25535-25542 (1999).
  • Ghosh, A., et al., J. Biol. Chem. 272(52):33220-33226 (1997).
  • Ghosh, S.K., et al., J. Biol. Chem. 266(23):15293-15299 (1991).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1.
NCBI Gene ID #:
4938
NCBI Official Name:
2'-5'-oligoadenylate synthase 1
NCBI Official Symbol:
OAS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
P00973
Protein GI Number:
296439492
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
P00973
User NOte:
Optimal dilutions for each application to be determined by the researcher.