ProSci

NeuroD1 Antibody

Product Code:
 
PSI-60-933
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Y79 cell line ,mouse cerebellum and rat brain tissue lysates (35ug/lane).
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Western blot analysis in Y79 cell line ,mouse cerebellum and rat brain tissue lysates (35ug/lane).

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PSI-60-933-400ul400ul£626.00
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Further Information

Additional Names:
Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3, NEUROD1, BHLHA3, NEUROD
Application Note:
For WB starting dilution is: 1:1000
Background:
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
Background References:
  • Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Miyachi, T., et al., Brain Res. Mol. Brain Res. 69(2):223-231 (1999). Malecki, M.T., et al., Nat. Genet. 23(3):323-328 (1999). Acharya, H.R., et al., Biochem. Biophys. Res. Commun. 233(2):459-463 (1997). Yokoyama, M., et al., Brain Res. Mol. Brain Res. 42(1):135-139 (1996).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NeuroD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-348 amino acids from the C-terminal region of human NeuroD1.
NCBI Gene ID #:
4760
NCBI Official Name:
Neurogenic differentiation factor 1
NCBI Official Symbol:
NEUROD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
Q13562
Protein GI Number:
311033428
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Obesity,Neuroscience
Swissprot #:
Q13562
User NOte:
Optimal dilutions for each application to be determined by the researcher.