Diaclone Biologically Active Antibodies
Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies.
Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies.
Available Biologically Active Antibodies
| Specificity (Anti-Human) | Clone | Azide Free | Biological Activity |
|---|---|---|---|
| CD10 | B-E3 | 854.090.000 | Cytotoxic In association with rabbit complement on CD10+ cells |
| CD102 / ICAM-2 | B-T1 | 852.760.000 | Inhibits cell adhesion and T-cell activation |
| CD106 / VCAM-1 | B-K9 | 852.770.000 | Inhibits cell attachment to VCAM-1 |
| CD117 / c-kit | B-K15 | 854.510.000 | Inhibits the KIT ligand induced proliferation of TF1 cell line |
| CD126 / IL-6R | B-R6 | 852.030.000 | Inhibits IL-6 induced proliferation of XG-1 cells |
| CD130 / gp130 | B-S12 | 852.110.000 | Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation |
| CD130 / gp130 | B-P4 | 852.090.000 | Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities |
| CD130 / gp130 | B-P8 | 852.080.000 | Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation |
| CD130 / gp130 | B-K5 | 852.070.000 | Inhibits CNTF activity. Inhibits OSM binding to gp130 |
| CD130 / gp130 | B-R3 | 852.060.000 | Inhibits IL-6, IL-11, CNTF, LIF and OSM activities |
| CD178/FAS-L | B-R17 | 853.070.000 | Inhibits soluble CD178 induced apoptosis |
| CD184 | B-R24 | 854.600.000 | Inhibits HIV-1 infection |
| CD2 / LFA-2 | B-E2 | 852.500.000 | Inhibits mixed lymphocyte culture |
| CD20 | B-H20 | 854.150.000 | Cytotoxic in association with complement on CD20 cells |
| CD202b / Tie-2 / TEK | B-B48 | 854.710.000 | Inhibits Tek-L / Tek binding |
| CD21 | B-E5 | 854.160.000 | Induces human B-cell proliferation and competes with EBV for CD21 binding |
| IL-18Ra | B-E43 | 854.900.000 | Inhibits human IFNγ secretion induced by IL-18 stimulated cells |
| IL-18Rb | B-B46 | 854.910.000 | Inhibits human IFNγ secretion induced by IL-18 stimulated cells |
| CD25 / IL-2R | B-F2 | 852.010.000 | Inhibits mixed lymphocyte culture |
| CD25 / IL-2R | B-B10 | 852.000.000 | Inhibits mixed lymphocyte culture |
| TRAIL / APO2L | B-T24 | 853.090.000 | Inhibits TRAIL induced apoptosis |
| TRAIL | B-S23 | 853.080.000 | Enhances TRAIL induced apoptosis |
| TRAIL R1 / DR4 | B-N36 | 854.850.000 | Neutralizes TRAIL induced apoptosis on HEL cell line |
| TRAIL R2 / DR5 | B-D37 | 854.870.000 | Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line |
| TRAIL R2 / DR5 | B-K29 | 854.860.000 | Neutralizes TRAIL induced apoptosis of U937 cell line |
| TRAIL R3 / DcR1 | B-D44 | 854.890.000 | Inhibits TRAIL binding to TRAIL R3 |
| CD28 | B-T3 | 854.220.000 | Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation. |
| CD3 | B-B11 | 854.010.000 | Induces T lymphocyte stimulation and proliferation |
| CD34 Class I | B-G25 | 854.240.000 | Triggers KG-1a cell aggregation |
| CD4 | B-A1 | 854.030.000 | Inhibits mixed lymphocyte culture |
| CD40 | B-B20 | 854.280.000 | Stimulates B-cell proliferation together with IL-4 |
| CD44 / PGP-1 | B-F24 | 852.600.000 | Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44 |
| CD54 | B-H17 | 852.690.000 | Inhibits PHA stimulated T-cell proliferation |
| CD86 | B-T7 | 854.450.000 | Inhibits mixed lymphocyte culture |
| CD95 / FAS | B-D29 | 853.030.000 | Inhibits FasL induced apoptosis |
| CD95 / FAS | B-G27 | 853.000.000 | Triggers Fas induced apoptosis |
| HLA Class I | W6/32 | 857.220.000 | Inhibits the interaction between T cells and MHC molecules |
| IFN gamma | B-B1 | 855.000.005 | Inhibits IFNγ induced proliferation |
| IL-10 | B-S10 | 855.100.005 | Inhibits IL-10 induced proliferation on MC/9 cell line |
| IL-12p35+p70 | B-T21 | 855.120.005 | Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes |
| IL-12p40+p70 | B-P24 | 855.130.005 | Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes |
| IL-13 | B-B13 | 855.140.005 | Inhibits IL-13 induced proliferation on TF1 cell line |
| IL-15 | B-E29 | 855.220.005 | Inhibits IL-15 induced proliferation on Kit 225 cell line |
| IL-17A | B-B51 | 853.910.005 | Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production) |
| IL-17F | B-F60 | 855.360.005 | Neutralises the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production) |
| IL-1beta | B-A15 | 855.010.005 | Inhibits IL-1β induced proliferation on D10S murine cell line |
| IL-2 | B-G5 | 855.020.005 | Inhibits IL-2 induced proliferation on CTL-L2 murine cell line |
| IL-23 | B-Z23 | 853.920.005 | Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production) |
| IL-4 | B-S4 | 855.030.005 | Inhibits IL-4 induced proliferation on TF1 cells |
| IL-6 | B-E8 | 855.050.005 | Inhibits IL-6 induced proliferation on B9 cells |
| IL-8 | B-K8 | 855.080.005 | Inhibits IL-8 induced chemotaxis of human neutrophils |
| NKp46 | B-L46 | 855.490.000 | Measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFNγ secretion by non-activated NK cells |
| Neurotensin | B-N6 | 857.040.000 | Inhibits neurotensin binding to its receptor |
| TNF alpha | B-C7 | 855.150.005 | Inhibits TNFα induced cytotoxicity on U937 cells |
Diaclone products are distributed In the UK and Ireland by Caltag Medsystems. If you have any questions about the products in this blog, please contact us.
Diaclone Biologically Active Antibodies