Through our network of trusted suppliers Caltag Medsystems are able to offer human diseased peripheral blood, plasma, serum, and peripheral blood mononuclear cells (PBMCs). Using suppliers strategically located collection centers we are able to ensure access to donors and the
Primary cells: Human Gastrointestinal Cells
The gastrointestinal (GI) system includes a number of highly specialised cell types each differentiated to perform a specific function. The most common are epithelial cells, which are diversely specialised to carry out most of the functions which are specific to
What’s the KD of my Antibody?
Understanding binding affinity is an important part of the drug discovery process, ensuring that therapeutic antibodies that bind their targets selectively and specifically. It also helps to understand the intermolecular interactions driving biological processes, structural biology, and structure-function relationships. KD
Protective role for IL-36 cytokines in obesity and metabolic disease
Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin inflammatory diseases, but also in the inflammation of lung or gut. Recently, the lab of Prof. Patrick T. Walsh
Stress granules inhibit NLRP3 inflammasome activation by sequestering the helicase DDX3X
Inflammasomes are large multimolecular complexes involved in innate immune response and driving cell fate towards cell death, called pyroptosis. Stress granules are aggregates formed during cellular stress with pro-survival role composed of proteins and mRNA molecules. Recently, the lab of
The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1
Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). In a recent study, the lab of
Extracellular Vesicles Containing eNAMPT Extend Lifespan
A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice
Fibrinogen-like Protein 1 (FGL1) – A Major Ligand of LAG-3
LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted
Protective Role of Irisin in Alzheimer’s Disease
Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 (FNDC5) and has a beneficial role in adipose tissues, bone and brain. A recent study published in Nature Medicine by the labs of O. Arancio, S.Ferreira & F.G.