BioArtificial Livers (BALs) HepaRG™ cells can be cultured in 3D bioreactors to generate an in-vivo-like assembly of highly polarised cells with high and sustained CYP activities. This makes them a promising cell type for use as liver assist devices or
In-vitro ADME Applications
Drug metabolism and clearance HepaRG™ cells are classified as an “average human hepatocyte population” and express multiple functional Phase 1 and 2 drug metabolising enzyme (DME) activities comparable to levels in cultures of primary human hepatocytes. This makes them a
Silensomes: One single model for DMPK phenotyping studies
Silensomes™ are human pooled liver microsomes in which one specific CYP has been chemically knocked out and are capable of directly quantifying and predicting the contribution of CYP enzymes in drug metabolism. Until now, a battery of in-vitro tests recommended by the regulatory
Request a Cell Culture Booklet
Caltag Medsystems: Your Cell Culture Provider Our Cell Culture portfolio ranges from primary cells, stem cells, cell lines and media to skin, fresh animal brains, healthy & diseased products, angiogenesis models and transfection reagents. We have put together a booklet to provide
Stem Cell Basics
Stem cells, by definition, can undergo infinite number of cell division while remain in an undifferentiated state. However, stem cells can also give rise to differentiated daughter cells that are committed to specialised cell fate in all three primary germ
Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)
Renal proximal tubular epithelial cells (PTEpiC) play a crucial role in renal function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the
Human Hepatic Stellate Cells
ScienCell’s Human Hepatic Stellate Cells (Product Code: SC-5300) cultured in Stellate Cell Medium (Product Code: SC-5301) is an optimal model for many research areas including liver injury, hepatic development, regeneration, xenobiotic responses, intermediary metabolism, and immunoregulation. Studying HHSteC will lead
Tailored Media for Proliferation and ECM Production
Traditional fibroblast media utilise 10% serum combined with very simple basal media formulations. The new CnT-PR-F medium uses an advanced basal medium formulation and a mix of defined growth factors to reduce the serum requirement down to 1%. As a
Features of Melanocyte Differentiation Medium
Traditional melanocyte media contain a mixture of signals and aim to provide both strong proliferation, whilst maintaining melanin expression and dendricity. However, the cells do not receive such mixed signals in vivo and are unable to provide all these behaviours
Double Keratinocyte Isolation Efficiency with Isoboost
Isolation is a considerable stress for primary cells, in which the physical detachment and loss of cohesion results in significant loss of viability and reduced attachment. The new IsoBoost supplement (CnT-ISO-50) is able to significantly boost the isolation efficiency of primary