Immunotherapies such as monoclonal antibodies, bispecific antibodies (Bi-specific T-cell engagers or BiTEs) and adoptive T-cell therapies (e.g. CAR-modified T-cell) have provided great advances in cancer treatment. However, testing new therapies is not without risk. The most common and potentially severe
What’s the KD of my Antibody?
Understanding binding affinity is an important part of the drug discovery process, ensuring that therapeutic antibodies that bind their targets selectively and specifically. It also helps to understand the intermolecular interactions driving biological processes, structural biology, and structure-function relationships. KD
BeCytes Biotechnologies: Liver Cells for Research – Animal Hepatocytes
BeCytes Biotechnologies offers a range of animal hepatocytes for research purposes.
What do mitochondria have to do with mitophagy?
What is mitophagy? It is when damaged mitochondria are removed from the cell by autophagy. The damaged mitochondria end up in lysosomes for their final disposal. This whole process is to maintain and assure proper cellular function. The importance of
Don’t FRET- You’ve got Fluoppi!
Visualizing protein-protein interaction (PPI) is pretty neat. You are able to glimpse into a really unique aspect of nature that many people don’t get to see. It’s like watching lions and zebras interact but without the bloody violence. However, anyone
Keima-Red for mitophagy detection in living cells
Mitophagy is the selective degradation of old or depolarised mitochondria by autophagy and contributes to maintaining a healthy population of mitochondria. Since damaged mitochondria lead to collapse cell homoeostasis, mitophagy is believed to be protective against diseases related to mitochondrial
FUCCI: Fluorescent Ubiquitination-based Cell Cycle Indicator
FUCCI (Fluorescent Ubiquitination-based Cell Cycle Indicator) is a set of fluorescent probes which enables the visualisation of cell cycle progression in living cells. FUCCI utilises the phase-dependent nature of replication licensing factors Cdt1 and Geminin. A fusion protein of a
Fluoppi: Fluorescence Image Based Protein-Protein Interaction Analysis
Protein-Protein Interaction in living cells No need for optimising linker High-throughput drug discovery system Fluoppi (Fluorescent based technology detecting Protein-Protein Interaction) is a novel technology to detect Protein-Protein Interaction (PPI) in living cells with a high signal to noise ratio.