KACTUS has demonstrated via ELISA & SPR binding assays that their MHC-peptide complexes & loaded peptide-ready MHCs have good binding affinity to TCRs.
KACTUS: MHC Monomer & Tetramer Product Validation Data
KACTUS: MHC Monomer & Tetramer Alleles
KACTUS have a range of Class I and Class II MHC Monomer and Tetramer alleles available.
Analytical Tools
All the analytical tools you need for your research: in vivo products, tetramers, ELISAs, small molecules & proteins (RUO & GMP)!
TCR Tetramers
A TCR Tetramer is a reagent prepared by tetramerising biotinylated antigen-specific TCRs with the help of phycobiliprotein-labelled streptavidin.
Non-classical MHC Tetramers
Non-classical Major Histocompatibility Complex (MHC) molecules are non-polymorphic proteins implicated in both innate and adaptive immune responses.1,2 While classical MHCs present antigens to CD8+/CD4+ cells for further immune processing, non-classical MHCs also mediate activation or inhibition in natural killer (NK) cells.3 MBL
CD1d
CD1d molecules are non-polymorphic MHC class I-like proteins. These are a type of non-classical MHCs. They present phospholipid and glycosphingolipid antigens to invariant Natural Killer T (iNKT) cells, a subset of CD1d-restricted T cells. This axis is involved in the
MHC Class II Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD4+ T cells, which include helper and regulatory T cells, recognise complexes of MHC class
MHC Class I Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments expressed on the surface of antigen-presenting cells. CD8+ T cells, also called cytotoxic T
Why is the MHC monomer the ideal choice for your experimental design?
The MHC Monomer is a sub-component of an MHC Tetramer. Biotinylated Monomers are available for most associated Tetramer products.
Flexibility and Expansion with BV421 Tetramers
Adding another marker to a flow cytometry panel can present a challenge when trying to accommodate all markers of interest in one panel. However, there is a solution.