Clinically relevant Mesenchymal Stem Cells

Rapid advancements in mesenchymal stem cells (MSCs) research are shedding light on disease processes of musculoskeletal tissue, tissue regeneration, immune modulation and epigenetics. To further the understanding of MSCs disease mechanisms and therapeutic approaches, we offer Renovos  research-grade mesenchymal stem cells, ethically sourced from osteoarthritic donors.

Why should you use Renovos MSCs?

Old vs Young cells

Why use Renovos’ MSCs from older patients rather than cells from healthy volunteers?

• Renovos MSCs are generally older providing a population of cells which will act closer to those found in the target patient demographic
• Renovos isolates MSCs from materials which would otherwise be waste from hip replacement operations
• Some suppliers treat MSCs with additional growth factors to enhance their proliferation potential, thereby altering normal behaviour and expression

Osteoarthritic vs Healthy

Why use Renovos’ MSCs from osteoarthritic patients rather than cells from healthy volunteers?

• Osteoarthritic cells are altered in expression, cell signaling, cell signaling responses and epigenetics, therefore treatments being developed to work on healthy cells may not work on osteoarthritic cells
• Using osteoarthritic cells in your assays will provide data more closely related to target demographics, and thereby more accurate screening of drugs, materials and treatment regimens for osteoarthritic patients
• Renovos MSCs are isolated from patients with osteoarthritic joints, rather than cells from healthy volunteers which are screened for such diseases
• Renovos isolates MSCs from materials which would otherwise be waste from hip replacement operations

Screened vs Non-screened

Why use Renovos’ MSCs rather than isolating cells yourself:

• Renovos’ MSCs have been screened for HIV, HBV and HCV and therefore lower risk for the researchers using them
• Renovos’ MSCs are screened for mycoplasma infection ensuring when you are using these cells no infection is passed to your cultures, and gene expressions and cell performance are not changed by mycoplasma
• Using Renovos cells reduces the time required for isolation in labs, as the cells are viable and growing for at least 10 more doublings from thawing
• Renovos MSCs are validated using flow cytometry ensuring the cells are positive for MSC markers and capable of multilineage differentiation