Nonhuman primates as preclinical models for evaluating immune function – MBL International

Nonhuman primates (NHP) resemble humans in multiple ways including similarities in genomics,  immunogenetics, and age-related changes in immune function. These characteristics are critical to the establishment of a relevant model in which to conduct preclinical studies to optimize the efficacy and safety of therapeutic approaches. 

Importantly, NHPs are vital preclinical models for viruses as viral infections are frequently associated with the same pathologies. Hence, NHPs are immune models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. Over numerous preclinical studies for human viral diseases, NHPs have demonstrated to be a beneficial benchmark for investigating human viral infections.

MBL International offers various nonhuman primates alleles for Rhesus macaques and Mauritian cynomolgus macaques and sequence combinations for human and mouse MHC tetramers. If you do not see your product of choice, please contact us for custom tetramer production.
MBLI tetramers are available in PE, APC, and BV421. In addition, biotinylated monomers are also available for assay flexibility and extension of fluorescent options via tetramerization using commercially available streptavidin conjugates.

Product Highlights:

REFERENCES:

• 1. Graveline, Richard, et al. “Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors.” Mabs. Vol. 14. No. 1. Taylor & Francis, 2022.
• 2. Ishii, Hiroshi, et al. “A novel immunogen selectively eliciting CD8+ T cells but not CD4+ T cells targeting immunodeficiency virus antigens.” Journal of Virology 94.8 (2020): e01876-19.

For Research Use Only.  Not for use in diagnostic procedures

Originally posted by MBL International Corp