The gastrointestinal (GI) system includes a number of highly specialised cell types each differentiated to perform a specific function. The most common are epithelial cells, which are diversely specialised to carry out most of the functions which are specific to
Fibrinogen-like Protein 1 (FGL1) – A Major Ligand of LAG-3
LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted
Innovative Applications of TransFix®
TransFix® is designed for stabilisation of peripheral blood and cerebrospinal fluid to enumerate lymphocyte subpopulations by flow cytometry. However, researchers have developed many new and innovative uses of TransFix. We’ve presented a selection of publications to highlight the versatility of
The Use of Immunotherapy in Treating HHV-6 Infection
Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection.
CHP Histopathology
After being degraded by specific enzymes, the triple helical collagen molecule becomes thermally unstable and spontaneously unfolds at body temperature, leaving denatured collagen fragments covalently crosslinked within the partially degraded matrix.[1,2] Such denatured collagen is a hallmark indicator of inflammation and tissue
Cell Culture Media
ScienCell Research Laboratories cell culture media ScienCell’s wide assortment of cell culture media is in liquid form and includes Specialty, Classical & Supplement varieties. Each product is designed for optimal nutrition and growth of primary cells. ScienCell’s media is manufactured
T Cell Immune Checkpoints for Immuno-Oncology Research
AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including recombinant proteins, antibodies and ELISA Kits.
Inflammasomes and Gasdermin D Signaling Pathways
AdipoGen Life Sciences have a range of reagents for Gasdermin research
Autoimmune Disease Biomarkers APRIL & BAFF
The B cell-stimulating molecules, BAFF (B cell activating factor, also known as BLyS; TALL-1; CD257 or TNFSF13B) and APRIL (a proliferation-inducing ligand, also known as CD256 or TNFSF13), are critical factors in the maintenance of the B cell pool and
3Helix Overview and Applications
Collagen is the most abundant protein in the human body. It is a critical component of almost all organs and tissues, providing the framework for cell attachment and growth. Collagen degradation regulates normal tissue remodelling which occurs during development, homeostasis