Immunohistochemistry (IHC) is a technique which is used to study the tissue distribution of a defined target. It relies on antibodies to detect specific proteins in a sample of tissue which has been paraffin embedded or frozen and can provide
Risk-Free™ Immune Checkpoints
ProSci Inc. offers an extensive range of antibodies and supporting tools to research Immune Checkpoints. Read more about their range below, or click a link to jump to a specific section: What Are Immune Checkpoints? What is Risk-Free™? Risk-Free™ Immune
PD-L1 Immune Checkpoint
PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. PD-L1 can bind to PD-1, which mediates inhibitory signals from the APC. ProSci Inc. offers an extensive range
PD-1 Immune Checkpoint
The PD-1 protein is a negative co-stimulatory receptor that can bind two different but related ligands, PD-L1 and PD-L2. Upon binding, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals.” ProSci Inc.
Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.
Mechanisms of Autophagy The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly
Aging and Telomere Length Quantification by qPCR
Aging is a time-dependent decline of the body’s functional capabilities and is an inevitable course of life (as shown in the image below, extracted from the Wall Street Journal). The rate of aging though is highly variable among individuals.
Inter-laboratory Comparison of the TransFix/EDTA Vacuum Blood Collection Tube (TVT) with the 5 mL Cyto-Chex® BCT
Cytomark, a division of Caltag Medsystems, recently presented a scientific poster at the ICCS2017 conference in collaboration with the Royal Hallamshire Hospital (Sheffield, UK), Royal Sussex County Hospital (Brighton, UK), and Roswell Park Cancer Institute (Buffalo, NY, USA). “Inter-laboratory Comparison of the TransFix/EDTA
Measure Immune Response & Treatment Efficacy with Diaclone ELISpot Kits
Monitoring the immune responses of patients treated with immunotherapy is essential to evaluate the efficacy of treatment and correlate clinical responses to Cytotoxic T Lymphocyte responses. Diaclone ELISPot assays are specific, accurate, sensitive, precise & robust. This bioassay is recognised
How To Choose The Appropriate Nanovesicle
The aim of this post is to explain how to choose the appropriate nanovesicle regarding its final application. Although nanovesicles have a lot of different applications, here we will discuss the most common: Intracellular delivery Controlled delivery In vitro assays In vivo assays Passive
News Release Research Article Cites Cleanascite™ for Macrophage Characterization of Sebum Lipids
Biotech Support Group reports on a recent research article describing the simplicity and efficiency of their lipid removal sample preparation product for the differentiation and activation of macrophages based on a sebum lipid profile. The citation is: Lovászi, M., et