Caltag Medsystems – Page 19 – UK distributor of antibodies, enzymes, kits and related products for use in research applications and clinical diagnosis.

Blog

GITR – GITRL Pathway

Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.

CD137 is an activating receptor binding to CD137L, expressed on natural killer (NK) cells & T cells, therefore triggering innate & adaptive immunity.

T cell immunoglobulin & mucin-3 (TIM-3; HAVcr-2) is an immune checkpoint receptor involved in the suppression of both innate & adaptive immune cells.

ICOS/ICOSL signalling leads to the activation, proliferation and survival of cytotoxic T cells, as well as the survival of memory T cells.

The PD-1/PD-L1 or PD-L2 signalling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production.

AdipoGen Life Sciences have comprehensive & unique reagents for microtubule research.

AdipoGen Life Sciences specialises in the development of recombinant proteins that show enhanced activity and stability, produced in mammalian cells.

AdipoGen’s Progranulin (human) ELISA Kit is the only kit that can detect all mutations in the progranulin gene.

AdipoGen Life Sciences provide high quality reagents for PAR & PARP research

PANoptosomes are involved in many diseases including autoinflammatory, metabolic & neurodegenerative diseases, cancer & microbial human infections.