Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin inflammatory diseases, but also in the inflammation of lung or gut. Recently, the lab of Prof. Patrick T. Walsh
Stress granules inhibit NLRP3 inflammasome activation by sequestering the helicase DDX3X
Inflammasomes are large multimolecular complexes involved in innate immune response and driving cell fate towards cell death, called pyroptosis. Stress granules are aggregates formed during cellular stress with pro-survival role composed of proteins and mRNA molecules. Recently, the lab of
The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1
Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). In a recent study, the lab of
Extracellular Vesicles Containing eNAMPT Extend Lifespan
A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice
Fibrinogen-like Protein 1 (FGL1) – A Major Ligand of LAG-3
LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted
Protective Role of Irisin in Alzheimer’s Disease
Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 (FNDC5) and has a beneficial role in adipose tissues, bone and brain. A recent study published in Nature Medicine by the labs of O. Arancio, S.Ferreira & F.G.
Manganese (Mn2+) as a New Activator of the NLRP3 Inflammasome in the Brain
Inflammasomes are implicated in physiological and pathological inflammation including neurodegenerative disorders such Parkinson or Alzheimer diseases. Divalent manganese (Mn2+) activates chronic inflammation leading to increase of neurotoxicity. Recently, the lab of A.G. Kanthasamy (Iowa State University, US) showed that Mn2+ activates
Erythroferrone (human) ELISA Kit – The only Specific & Sensitive Assay on the Market!
Sandwich ELISA Kit based on two antibodies for the in vitro quantitative determination of human Erythroferrone in supernatants, serum and plasma.
Apoptosis Detection Kits
In general, early apoptosis can be determined by Mitochondrial membrane ΔΨm assay, Annexin V-FITC/PI assay and Caspase-3 assay. Late apoptosis can be determined by TUNEL, DNA ladder assay and DNA content analysis. Elabscience® provides simple and sensitive solutions for detection