Chimeric Antigen Receptor (CAR) T cell therapy is a revolutionary approach in the field of cancer immunotherapy.
Chimeric Antigen Receptor (CAR) T Cell Therapy
The Dark Side of CAR-T Therapy – Cytokine Release Syndrome (Diaclone)
Immunotherapies such as monoclonal antibodies, bispecific antibodies (Bi-specific T-cell engagers or BiTEs) and adoptive T-cell therapies (e.g. CAR-modified T-cell) have provided great advances in cancer treatment. However, testing new therapies is not without risk. The most common and potentially severe
February 2017: The Antibody Update
Epidermal Levels of Staphylococcus Aureus Are Affected by a Peptide Produced by Other Skin Dwelling Bacteria Staphylococcus aureus is common to many of people’s ski n microbiome, and is generally harmless; however, in high population density the bacteria can lead to atopic
Problems with Immunotherapy
Pairs of proteins that act as T-cell co-signaling receptors are called immune checkpoints. These cell surface receptors can send positive or negative signals to T cells, instigating a response from the immune system to either stimulate the immune system against
T-cell Activation: The Purpose of CD28, CTLA-4, and CD80/CD86
A Guide to CD28, CTLA-4, and CD80/CD86 Interaction and Signaling Immune checkpoint receptors like CD28 and CTLA-4 have been of great interest in the research of cancer immunotherapy. These receptors and their ligands are part of what regulates T-cell activation
December 2016: The Antibody Update
Merck’s Ebola Vaccine is 100% Effective An extremely effective Ebola virus vaccine created by Merck was recently tested in Guinea with 100% effectiveness. Though the vaccine is late for the worst part of the infection, the results are so promising
November 2016: The Antibody Update
China Perform First Injection of CRISPR Modified Cells into a Person Use of CRISPR-Cas9 in human cells for treatment of disease has been a controversial topic amongst scientists since the discovery of the powerful gene editing tool. In this clinical
October 2016: The Antibody Update
The Nobel Prize in Medicine was Awarded to Yoshinori Ohsumi for His Work on Autophagy Autophagy is the cellular process that regulates a cells ability to degrade parts of itself that must be replaced. Yoshinori Ohsumi’s work in autophagy has proven to
June 2016: The Antibody Update from ProSci
This months ProSci Antibody Update’s news includes the first CRISPR/Cas9 cancer therapeutic’s entry into clinical trials, how mosquito saliva assists viruses in proliferation, and the latest update on antibody validation. First CRISPR/Cas9 Therapeutic Clinical Trials StartingProSci Blog Antibody UpdateCRISPR Cas9
“Let’s Make America the Country That Cures Cancer Once and For All”
During the 2016 State of the Union Address, President Obama called attention to a myriad of issues currently plaguing Americans. One of the many initiatives President Obama announced in response was a “moonshot” to cure cancer, referencing the flood of