In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) MBL International described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether that
How to Identify SARS-CoV-2 Virus Derived Peptides
In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research), MBL International describes how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether
Find Human MHC Class I Dominant Peptides
In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) MBL International described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether
Comparing Theoretical Peptide-MHC Binding Affinity to Real Values produced by the QuickSwitch™ Platform
In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) MBL International described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether
How to screen SARS-CoV-2 peptides to facilitate T cell research
Whenever our immune system is faced with a challenge, be it a multicellular parasite, a bacteria, a virus, or even cancer, this threat is detected and sampled primarily by the protein sequence of the pathogen in question. Other aspects of
MHC Class I & II Tetramers, MHC Monomers and CD1d Tetramers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. We have tetramerized and biotinylated with streptavidin to maintain stable binding to multiple TCR, enabling MHC/peptide tetramers to be used
Monomers
Biotinylated MHC monomers, the building blocks of MHC tetramers, are now available for tetramer construction flexibility and novel applications. See All Monomer Products
The Use of Immunotherapy in Treating HHV-6 Infection
Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection.
Tips for Staining Rare Antigens with MHC Tetramers
When performing staining with MHC tetramers, there may be certain cases where the staining is unclear. An example could be in certain cases where an antigen-specific T cell population of interest has a low frequency. The following tips discussed in
White Paper: Role of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease
In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this