The UPS and the autophagic-lysosomal pathway are the two major degradation systems for native & misfolded proteins in eukaryotic cells.
The Ubiquitin-Proteasome System
![The Ubiquitin-Proteasome System The Ubiquitin-Proteasome System](https://www.caltagmedsystems.co.uk/information/wp-content/uploads/UPS-600x400px-600x300.png)
The UPS and the autophagic-lysosomal pathway are the two major degradation systems for native & misfolded proteins in eukaryotic cells.