The Diaclone name has stood for quality and reliability for 34 years. Based in Besançon, France, Diaclone pride themselves on excellence in monoclonal antibody and immunoassay development and manufacture.
The expanding range of Diaclone immunology products is specifically designed to advance research applications. Here is a selection of fresh additions to their catalogue for 2020:
IL-28A & IL-28B: anti-proliferative and anti-tumor activity
IL-28A, IL-28B, and IL-29, also named interferonλ2 (IFNλ2), IFNλ3, and IFNλ1, respectively, are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and upregulation of MHC class I antigen expression. They signal through the same heterodimeric receptor complex that is composed of the IL10 receptor β (IL10Rβ) and a novel IL28 receptor α (IL28 Rα, also known as IFNλR1).
The three proteins have been reported to have an anti-proliferative and antitumor activity.
New Diaclone IL-28A Antibodies
- Anti-Human IL-28A B-H44 Azide Free 857.640.000 / 857.640.005
- Anti-Human IL-28A B-Z28 Azide Free 857.660.000 / 857.660.005
- Anti-Human IL-28B B-L48 Azide Free 857.680.000 / 857.680.005
View all Diaclone Interleukin antibodies
CD38: highly expressed in haematological malignancies
CD38 is an enzyme involved in synthesis and hydrolysis of cyclic ADP-ribose (cADPR), essential for the regulation of intracellular Ca2+. It is also a cell activation marker. A loss of its function is associated with impaired immune responses or metabolic disturbances.
The CD38 is a type II transmembrane glycoprotein highly expressed in haematological malignancies including multiple myeloma (MM) and represents a promising target for mAb-based immunotherapy.
New Diaclone CD38 Antibodies
- Anti-Human CD38 B-E60 Azide Free 857.920.000 / 857.920.005
View all Diaclone Cluster of differentiation antibodies
I-TAC: biomarker for heart failure, left ventricular dysfunction and GVHD
I-TAC (for interferon-inducible T-cell alpha chemoattractant) is a small cytokine belonging to the CXC chemokine family that is also called C-X-C motif chemokine 11 and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.
CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction and it was also described than CXCL10 and CXCL11 as useful diagnostic biomarkers for acute GVHD and chronic GVHD.
New Diaclone I-TAC Antibodies
- Anti-Human I-TAC B-S40 Azide Free 857.700.000 / 857.700.005
- Anti-Human I-TAC B-K43 Azide Free 857.650.000 / 857.650.005
Galectin-8: Cellular Adhesion inhibitor widely expressed in tumour tissue
The galectin-8 is a 25KD membrane protein, and as all members of galectins family, it is a beta-galactoside-binding animal lectin with conserved carbohydrate recognition domains. Galectin-8 is also known as prostate carcinoma tumour antigen 1 (PCTA1) in human. Various studies showed that galectin-8 is widely expressed in tumour tissues as well as in normal tissues. Due to its dual effects on the adhesive properties of cells and its association with ibronectin, galectin might be considered as a novel type of a matricellular protein. The soluble form of Galectin-8 can inhibit cell adhesion.
New Diaclone Galectin-8 Antibodies
- Anti-Human Galectin-8 B-S36 Azide Free 857.690.000 / 857.690.005
View all Diaclone Galectin antibodies
IL-17C: promotes antibacterial inflammatory responses and linked to psoriasis
The IL-17C belongs to IL-17 family including also IL17A, IL-17B, IL-17D, IL-17E (IL-25) and IL-17F which all members have a similar protein structure. IL-17C is up-regulated during inflammation and is detected in lung and skin tissues after infection by mycoplasma pneumoniae and Staphylococcus aureus and in psoriatic skin lesions. Even if IL-17C has been reported to induce the expression of proinflammatory cytokines, its biological function is still largely unexplored. It has been found that IL-17C is an epithelial cell-derived cytokine which seems to play a role equivalent to IL-17A as promoting protective antibacterial immune responses at epithelial surfaces but may also have pathological functions in diseases such as psoriasis, in which the epithelial barrier is dysfunctional.
New Diaclone IL-17C Antibodies
- Anti-Human IL-17C B-A60 Azide Free 857.670.000 / 857.670.005
- Anti-Human IL-17C B-Z17 Azide Free 857.710.000 / 857.710.005
Related Blogs:
- Diaclone ELISpot: Ex-vivo Analysis of Protein Secretion
- Diaclone ELISA Kits and ELISA Sets
- Diaclone Biologically Active Antibodies
- Diaclone DIAplex
How can we help?
If you have any questions about Diaclone’s range off immunoassay products, or are looking for something in particular, please feel free to contact us!