Nordic MuBio

Rabbit anti Human Degenerative Spermatocyte Homolog 2

Product Code:
 
EXA-X2357P
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X2357P100 ug£316.00
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  • Further Information
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Further Information

Applications Description:
Antibody can be used for Western blotting (1-5 ?g/ml starting dilution). Optimal concentration should be evaluated by serial dilutions.
Background:
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9. Belongs to the fatty acid desaturase family. DEGS subfamily. Highly expressed in skin, intestine and kidney.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from human DEGS2 protein.
Positive Control:
Highly expressed in skin, intestine and kidney.
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Synonyms:
DEGS2; Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
UniProt:
Q6QHC5 (Human)

References

1. Mizutani, Y., et al. 'Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.; FEBS Lett. 563:93-97(2004).

2. Omae, F., et al. 'DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.' Biochem J. 2004 May 1;379(Pt 3):687-95.

3. Omae, F. et al. 'Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2.' FEBS Lett. 2004 Oct 8;576(1-2):63-7.

4. Enomoto, A., et al. 'Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.' Biochem J. 2006 Jul 15;397(2):289-95.