Antibody Clonality:
Monoclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
ROCK1 Antibody: ROCK-I, P160ROCK, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, ROCK-I
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
IP: 1:20 - 1:50
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant protein of human ROCK1
6093
Rho-associated, coiled-coil containing protein kinase 1
ROCK1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 158kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Signal Transduction
Q13464
Optimal dilutions for each application to be determined by the researcher.