Further Information
SEPT5, CDCREL-1, CDCREL1, H5, HCDCREL-1, Peanut-like 1 (Drosophila), Peanut-like 1, Peanut-like protein 1, Septin 5, Septin-5, CDCREL, PNUTL1
WB: 1:500 - 1:2000
IHC: 1:100 - 1:200
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human SEPT5 (NP_002679.2).
5413
septin 5
SEPT5.
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 43kDa
Affinity purification
Cell Cycle, Chemokines & Cytokines, Immunology, Neuroscience, Signal Transduction
Q99719
Optimal dilutions for each application to be determined by the researcher.