Further Information
putative liver tumor regressor, liver-expressed antimicrobial peptide, PLTR, LEAP1, LEAP-1, HFE2B, HEPCIDIN, HEPC, hepcidin antimicrobial peptide, HAMP, UNQ487/PRO1003
WB: 1:500 - 1:2000
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human HAMP (NP_066998.1).
57817
hepcidin antimicrobial peptide
HAMP
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 10kDa
Affinity purification
Immunology, Innate Immunity, Signal Transduction
P81172
Optimal dilutions for each application to be determined by the researcher.