IDE Antibody, KO Validated
Antibody Clonality:
Polyclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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This product comes from:
United States.
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14-21 working days.
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Further Information
insulin-degrading enzyme, FLJ35968, INSULYSIN, insulinase, insulysin
WB: 1:500 - 1:2000
IF: 1:10 - 1:100
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IDE (NP_004960.2).
3416
insulin-degrading enzyme
IDE
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 118kDa
Affinity purification
Cancer, Cell Cycle, Growth Factors, Neuroscience, Signal Transduction
P14735
Optimal dilutions for each application to be determined by the researcher.
Antibody is Knockout validated.