Antibody Clonality:
Polyclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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United States.
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Further Information
CORS1, CPD4, JBTS1, MORMS, PPI5PIV, pharbin, 72 kDa inositol polyphosphate 5-phosphatase, phosphatidylinositol polyphosphate 5-phosphatase type IV, phosphatidylinositol-4,5-bisphosphate 5-phosphatase
WB: 1:500 - 1:2000
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2).
56623
inositol polyphosphate-5-phosphatase E
INPP5E
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 80kDa
Affinity purification
Signal Transduction
Q9NRR6
Optimal dilutions for each application to be determined by the researcher.