Further Information
SHC1, FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
A synthetic peptide of human SHC1
6464
SHC (Src homology 2 domain containing) transforming protein 1
SHC1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 46kDa, 52kDa, 66kDa
Affinity purification
Cell Cycle, Immunology, Neuroscience, Signal Transduction
P29353
Optimal dilutions for each application to be determined by the researcher.