Further Information
STAT5A, signal transducer and activator of transcription 5A, MGF, STAT5
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 635-794 of human STAT5A (NP_003143.2).
6776
signal transducer and activator of transcription 5A
STAT5A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 90kDa
Affinity purification
Apoptosis, Cell Cycle, Immunology, Signal Transduction, Stem Cell, Transcription
P42229
Optimal dilutions for each application to be determined by the researcher.