Further Information
SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15
WB: 2 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples. All other applications and species not yet tested.
SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
- Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.
- Angata et al. Glycobiology 2007; 17:838-46.
- Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.
SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Anti-SIGLEC15 antibody (9017) was raised against a peptide corresponding to 14 amino acids near the carboxy?terminus of human SIGLEC15.
The immunogen is located within amino acids 270-320 of SIGLEC15.
Human SIGLEC15 has 2 isoforms, including isoform 1 (328aa, 36kD) and isoform 2 (174aa, 18kD). Mouse SIGLEC15 has one isoform (342aa, 37kD) and Rat SIGLEC15 also has one isoform (341aa, 37kD). 9017 can detect human and possibly mouse and rat isoforms.
284266
sialic acid binding Ig-like lectin 15
SIGLEC15
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 36kD
Observed: 34-36kD
NP_998767
47106069
SIGLEC15 Antibody is affinity chromatography purified via peptide column.
Immunology
Q6ZMC9
Optimal dilutions for each application to be determined by the researcher.