NSJ Bioreagents

MVP Antibody / Major Vault Protein

Product Code:
 
NSJ-V3042
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1014
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
 
Store the Major Vault Protein antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
1 / 2
Immunofluorescent staining of human A549 cells with Major Vault Protein antibody (green, clone 1014) and Reddot nuclear stain (red).~
2 / 2
Western blot testing of HeLa cell lysate with Major Vault Protein antibody (clone 1014). Observed molec
❮❯

Immunofluorescent staining of human A549 cells with Major Vault Protein antibody (green, clone 1014) and Reddot nuclear stain (red).~
Western blot testing of HeLa cell lysate with Major Vault Protein antibody (clone 1014). Observed molec

No additional charges, what you see is what you pay! *

CodeSizePrice
NSJ-V3042-20UG20 ug£264.00
Quantity:
NSJ-V3042-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Application Details :
Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml
Application Note:
Optimal dilution of the Major Vault Protein antibody should be determined by the researcher.
Description:
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Immunogen:
Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the Major Vault Protein antibody.
Limitation:
This Major Vault Protein antibody is available for research use only.
Localization:
Cytoplasmic, nuclear
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
Q14764