NSJ Bioreagents

HDAC1 Antibody

Product Code:
 
NSJ-F52270
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgM, k
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1061CT1.3.1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the HDAC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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HDAC1 antibody western blot analysis in (1) HeLa, (2) WiDr, and (3) Jurkat lysate. Predicted molecular weight ~60 kDa
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HDAC1 antibody western blot analysis in (1) HeLa, (2) WiDr, and (3) Jurkat lysate. Predicted molecular weight ~60 kDa

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CodeSizePrice
NSJ-F52270-0.08ML0.08 ml£260.00
Quantity:
NSJ-F52270-0.4ML0.4 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western blot: 1:1000
Application Note:
Titration of the HDAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
Purified His-tagged protein was used to produced this monoclonal HDAC1 antibody.
Limitation:
This HDAC1 antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human
Uniprot #:
Q13547