NSJ Bioreagents

CD74 / CLIP Antibody

Product Code:
 
NSJ-V3036
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
CLIP/1133
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store the CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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Western blot analysis of Raji cell lysate using CLIP antibody (CLIP/1133). Expected molecular weight: 33-43 kDa.

Western blot analysis of Raji cell lysate using CLIP antibody (CLIP/1133). Expected molecular weight: 33-43 kDa.

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CodeSizePrice
NSJ-V3036-20UG20 ug£264.00
Quantity:
NSJ-V3036-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details :
Western blot: 1-2ug/ml
Application Note:
Optimal dilution of the CLIP antibody should be determined by the researcher.
Description:
Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Immunogen:
Recombinant full-length human protein was used as the immunogen for the CLIP antibody.
Limitation:
This CLIP antibody is available for research use only.
Localization:
Cell surface and paranuclear globular
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
P04233