NSJ Bioreagents

BRCC36 Antibody

Product Code:
 
NSJ-F53844
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the BRCC36 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of human 1) heart and 2) brain lysate with BRCC36 antibody at 1:1000. Predicted molecular weight: 36 kDa.
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Western blot testing of human 1) heart and 2) brain lysate with BRCC36 antibody at 1:1000. Predicted molecular weight: 36 kDa.

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CodeSizePrice
NSJ-F53844-0.05ML0.05 ml£260.00
Quantity:
NSJ-F53844-0.2ML0.2 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western blot: 1:500-1000
Description:
BRCA1/BRCA2 containing complex subunit 36 is a metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Gene ID #:
79184
Immunogen:
A portion of amino acids 36-70 from the human protein was used as the immunogen for the BRCC36 antibody.
Limitation:
This BRCC36 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
P46736