NSJ Bioreagents

ATF4 Antibody

Product Code:
 
NSJ-F42021
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot the ATF4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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ATF4 antibody western blot analysis in (1) Jurkat and (2) MCF-7 lysate
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ATF4 antibody western blot analysis in (1) Jurkat and (2) MCF-7 lysate

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CodeSizePrice
NSJ-F42021-0.08ML0.08 ml£260.00
Quantity:
NSJ-F42021-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:1000
Application Note:
Titration of the ATF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
ATF4 is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. [UniProt]
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 171-198 from the human protein was used as the immunogen for this ATF4 antibody.
Limitation:
This ATF4 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
P18848