TargetMol

CHMFL-EGFR-202

Product Code:
 
TAR-T10802
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10802-1mg1mg£164.00
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TAR-T10802-2mg2mg£211.00
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TAR-T10802-5mg5mg£286.00
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TAR-T10802-1mL1 mL * 10 mM (in DMSO)£329.00
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TAR-T10802-10mg10mg£388.00
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TAR-T10802-25mg25mg£546.00
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TAR-T10802-50mg50mg£736.00
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TAR-T10802-100mg100mg£978.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).
CAS:
2089381-40-6
Formula:
C25H24ClN7O2
Molecular Weight:
489.96
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9919
SMILES:
NC1=C2C(=NN(C2=NC=N1)[C@H]3CN(C(C=C)=O)CCC3)C4=CC(Cl)=C(OCC5=CC=CC=N5)C=C4
Target:
EGFR

Documents

References

1. Wang A, et al. Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.