TargetMol

Maytansine

Product Code:
 
TAR-T21351
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21351-5mg5mg£118.00
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TAR-T21351-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T21351-10mg10mg£149.00
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TAR-T21351-25mg25mg£262.00
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  • Further Information
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Further Information

Bioactivity:
Maytansine, an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
CAS:
35846-53-8
Formula:
C34H46ClN3O10
Molecular Weight:
692.2
Pathway:
Microbiology/Virology; Cytoskeletal Signaling
Purity:
0.9962
SMILES:
CO[C@@H]1C=CC=C(C)Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(C)=O)[C@]2(C)O[C@H]2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
Target:
Microtubule Associated; Antibiotic

Documents

References

1. Kusari S, Lamsh?ft M, Kusari P, Gottfried S, Z?hlke S, Louven K, Hentschel U, Kayser O, Spiteller M. Endophytes are hidden producers of maytansine in Putterlickia roots. J Nat Prod. 2014 Dec 26;77(12):2577-84. 2. Tang X, Dai H, Zhu Y, Tian Y, Zhang R, Mei R, Li D. Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity. Am J Transl Res. 2014 Oct 11;6(5):528-37. eCollection 2014. 3. Wings S, M?ller H, Berg G, Lamsh?ft M, Leistner E. A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa. Phytochemistry. 2013 Jul;91:158-64. 4. Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, Jordan MA. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99.