TargetMol

Difelikefalin (trifluoroacetate salt)

Product Code:
 
TAR-T37483
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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TAR-T37483-10mg10mgEnquire
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TAR-T37483-1mg1mgEnquire
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TAR-T37483-5mg5mgEnquire
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Further Information

Bioactivity:
Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50= 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50= >1 μM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively).
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

Documents

References

Schteingart, C.D., Menzaghi, F., Jiang, G., et al.Synthetic peptide amides(2008)