TargetMol

AK-7

Product Code:
 
TAR-T5490
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5490-2mg2mg£104.00
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TAR-T5490-5mg5mg£125.00
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TAR-T5490-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T5490-10mg10mg£156.00
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TAR-T5490-25mg25mg£229.00
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TAR-T5490-50mg50mg£349.00
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TAR-T5490-100mg100mg£528.00
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  • Further Information
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Further Information

Bioactivity:
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
CAS:
420831-40-9
Formula:
C19H21BrN2O3S
Molecular Weight:
437.35
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.984
SMILES:
Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1
Target:
Sirtuin

Documents

References

Frid?n-Saxin, Maria, Seifert T , Landergren, Marie Ryd?n, et al. Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors[J]. Journal of Medicinal Chemistry, 2012, 55(16):7104-7113. Taylor DM, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. Machado D O R , Jana S , Kazantsev A G , et al. SIRT2 as a Therapeutic Target for Age-Related Disorders[J]. Frontiers in Pharmacology, 2012, 3.