Cyclothialidine

Product Code:

TAR-T23924

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T23924-100mg

100mg

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TAR-T23924-50mg

50mg

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Further Information

Bioactivity:

Cyclothialidine is an inhibitor of DNA gyrase.

CAS:

147214-63-9

Formula:

C26H35N5O12S

Molecular Weight:

641.65

Purity:

0.98

SMILES:

C[C@H](NC(=O)[C@@H]1CSCc2c(O)cc(O)c(C)c2C(=O)OC[C@H](NC(=O)[C@@H]2[C@H](O)CCN2C(=O)[C@@H](N)CO)C(=O)N1)C(O)=O

Documents

References

1. Mayer C, Janin YL. Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism. Chem Rev. 2014 Feb 26;114(4):2313-42. doi: 10.1021/cr4003984. Epub 2013 Dec 6. Review. PubMed PMID: 24313284. 2. Singh V, Chaudhary DK, Mani I. Gene network analysis of Aeromonas hydrophila for novel drug target discovery. Syst Synth Biol. 2012 Jun;6(1-2):23-30. doi: 10.1007/s11693-012-9093-z. Epub 2012 May 22. PubMed PMID: 23730361; PubMed Central PMCID: PMC3424198. 3. Singh SB, Young K, Miesel L. Screening strategies for discovery of antibacterial natural products. Expert Rev Anti Infect Ther. 2011 Aug;9(8):589-613. doi: 10.1586/eri.11.81. Review. PubMed PMID: 21819327. 4. Sa?z-Urra L, Cabrera P?rez M?, Helguera AM, Froeyen M. Combining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Eur J Med Chem. 2011 Jul;46(7):2736-47. doi: 10.1016/j.ejmech.2011.03.061. Epub 2011 Apr 5. PubMed PMID: 21530019.