TargetMol

Rooperol

Product Code:
 
TAR-T26121
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, antibacterial, anticonvulsant, and antioxidant activities. It is a novel p38α inhibitor.
CAS:
83644-00-2
Formula:
C17H14O4
Molecular Weight:
282.295
Purity:
0.98
SMILES:
Oc1ccc(C=CCC#Cc2ccc(O)c(O)c2)cc1O

Documents

References

1. Ali Azouaou S, Emhemmed F, Idris-Khodja N, Lobstein A, Schini-Kerth V, Muller CD, Fuhrmann G. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells. Invest New Drugs. 2015 Feb;33(1):64-74. doi: 10.1007/s10637-014-0182-6. Epub 2014 Nov 19. PubMed PMID: 25404486. 2. Boukes GJ, van de Venter M. Rooperol as an antioxidant and its role in the innate immune system: an in vitro study. J Ethnopharmacol. 2012 Dec 18;144(3):692-9. doi: 10.1016/j.jep.2012.10.014. Epub 2012 Oct 17. PubMed PMID: 23085395. 3. Kabanda MM. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study. Chem Res Toxicol. 2012 Oct 15;25(10):2153-66. doi: 10.1021/tx300244z. Epub 2012 Sep 17. PubMed PMID: 22946567. 4. Li J, Kaoud TS, LeVieux J, Gilbreath B, Moharana S, Dalby KN, Kerwin SM. A fluorescence-based assay for p38? recruitment site binders: identification of rooperol as a novel p38? kinase inhibitor. Chembiochem. 2013 Jan 2;14(1):66-71. doi: 10.1002/cbic.201200529. Epub 2012 Dec 6. PubMed PMID: 23225637; PubMed Central PMCID: PMC3775607.