TargetMol

Ropizine

Product Code:
 
TAR-T26122
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T26122-100mg100mgEnquire
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  • Further Information
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Further Information

Bioactivity:
Ropizine is a benzhydryl piperazine that acts as an allosteric modifier to decreases the dissociation rate of [3H]DM so that can be used as an anticonvulsant.
CAS:
3601-19-2
Formula:
C24H26N4
Molecular Weight:
370.5
Purity:
0.98
SMILES:
Cc1cccc(C=NN2CCN(CC2)C(c2ccccc2)c2ccccc2)n1

Documents

References

1. Canoll PD, Smith PR, Musacchio JM. Ropizine concurrently enhances and inhibits [3H]dextromethorphan binding to different structures of the guinea pig brain: autoradiographic evidence for multiple binding sites. Life Sci. 1990;46(19):PL9-16. PubMed PMID: 2345483. 2. Edmonds HL Jr, Bellin SI, Chen FC, Hegreberg GA. Anticonvulsant properties of ropizine in epileptic and nonepileptic beagle dogs. Epilepsia. 1978 Apr;19(2):139-46. PubMed PMID: 639771. 3. Klein M, Musacchio JM. Computer-assisted analysis of dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. Life Sci. 1990;47(18):1625-34. PubMed PMID: 2250576. 4. Klein M, Musacchio JM. High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. J Pharmacol Exp Ther. 1992 Mar;260(3):990-9. PubMed PMID: 1312173.