TargetMol

Roxindole

Product Code:
 
TAR-T26126
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26126-5mg5mg£650.00
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  • Further Information
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Further Information

Bioactivity:
Roxindole is an effective autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. It was originally developed for the therapy of schizophrenic syndromes.
CAS:
112192-04-8
Formula:
C23H26N2O
Molecular Weight:
346.474
Purity:
0.98
SMILES:
Oc1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1

Documents

References

1. Newman-Tancredi A, Cussac D, Audinot V, Millan MJ. Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53. PubMed PMID: 10431754. 2. Maj J, Kolodziejczyk K, Rog?z Z, Skuza G. Roxindole, a potential antidepressant. I. Effect on the dopamine system. J Neural Transm (Vienna). 1996;103(5):627-41. PubMed PMID: 8811507. 3. Seyfried CA, Bartoszyk GD. Sensitivity of dopamine D2 receptors following long-term treatment with roxindole. Eur J Pharmacol. 1994 May 12;257(1-2):67-72. PubMed PMID: 7915991. 4. Gr?nder G, Wetzel H, Hillert A, Jochum E, Hiemke C, Benkert O. The neuroendocrinological profile of roxindole, a dopamine autoreceptor agonist, in schizophrenic patients. Psychopharmacology (Berl). 1995 Feb;117(4):472-8. PubMed PMID: 7604150.