TargetMol

Sophoridine

Product Code:
 
TAR-T3339
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T3339-1mL1 mL * 10 mM (in DMSO)£107.00
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Quantity:
TAR-T3339-20mg20mg£111.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
CAS:
6882-68-4
Formula:
C15H24N2O
Molecular Weight:
248.37
Pathway:
DNA Damage/DNA Repair; Apoptosis
Purity:
0.9928
SMILES:
O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H](CN12)[C@@H]34
Target:
Apoptosis; Topoisomerase

Documents

References

Li X, et al. Bioorg Med Chem Lett. 2011, 21(18):5251-4.