Leinco Technologies

UltraAvidin™- PE

Product Code:
 
LEI-A104
Product Group:
 
Other Proteins
Host Type:
 
Chicken
Regulatory Status:
 
RUO
Shipping:
 
2-8°C
Storage:
 
This PE conjugate is stable when stored at 2-8°C. Do not freeze.
 

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CodeSizePrice
LEI-A104-0.25mg0.25 mg£188.00
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Further Information

Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
R-phycoerythrin (PE)
Format:
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
UltraAvidin™ is Leinco Technologies' trademark for a uniquely modified form of avidin which is isolated from chicken egg whites. With a molecular weight of 60,000, there are four identical subunits each capable of binding one molecule of biotin. UltraAvidin from Leinco Technologies has been de-glycosylated to prevent carbohydrate moieties from adhering to lectin-like receptors on the surface of cells, thus eliminating the possibility of false positives. Unlike native avidin, UltraAvidin has a near neutral pI which prevents electrostatic interactions with negatively charged serum or membrane proteins. Recent studies have identified a universal recognition sequence in streptavidin which is similar to that found in several adhesion receptors.4 It is a tripeptide sequence Arg-Tyr-Asp (RYD) which mimics the Arg-Gly-Asp (RGD) binding sequence of fibronectin. Strong interactions have been shown with streptavidin and cell surface molecules. This universal recognition sequence is not present in UltraAvidin. UltraAvidin may not significantly increase sensitivity in all research systems but will help assure specificity.

References

1. Frelinger, JA. et al. (2007) Blood. 109(8): 3300?3307. PubMed 2. R?nia, L. et al. (2003) Infect Immun. 71(6):3648-51. PubMed 3. R?nia, L. et al. (2002) J Immunol. 169(11):6369-75. Article Link 4. Wilchek, M. et al. (1990) Biochem Biophys Res Commun.170(3):1236-41. 5. Sullivan, W. et al. (1996) Genetics. 143(4):1629-42.