Leinco Technologies

Anti-Mouse CD32/CD16 - Purified in vivo GOLD™ Functional Grade

Product Code:
 
LEI-C381
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
2.4G2
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Blocking
  • Flow Cytometry
  • Functional Study
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Spatial Biology
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-C381-1.0mg1.0 mg£175.00
Quantity:
LEI-C381-5.0mg5.0 mg£380.00
Quantity:
LEI-C381-25mg25 mg£1,014.00
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LEI-C381-50mg50 mg£1,556.00
Quantity:
LEI-C381-100mg100 mg£2,159.00
Quantity:
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This product comes from: US.
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Further Information

Antigen Distribution:
These receptors are present on B cells, monocyte/macrophages, NK cells, neutrophils, mast cells and dendritic cells.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Sorted pre-B cells
Long Description:
CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.
NCBI Gene:
1413014131
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD32/CD16

References

1.) Titas, J. A. et al. (1982) J. Immunol. 133:556 2.) Rodewald, H. et al. (1992) Cell 69:139 3.) Skyberg, J. A. et al. (2020) Infection and Immunity. 88: 5 4.) Forte et al. (2020) Cell Reports. 30:3149?3163 Journal Link 5.) Forte, E. et al. (2020) Cell Reports 30(9):3149-3163.e6 Journal Link